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Studies have examined the relationship between NNMT inhibition and cellular NAD+ levels, which are critical for numerous enzymatic reactions including those involving sirtuins and PARPs

Additionally, monitoring biomarkers could guide treatment duration and dose adjustments, moving beyond one-size-fits-all protocols toward personalized therapeutic approaches optimized for individual patient characteristics and treatment goals

It is worth noting that dysregulation of DNA methylation patterns has been linked to various brain disorders, including depression, anxiety, and cognitive decline (reviewed in: 14,15 )

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